反应详情

温度

50 °C

To a solution of 4-trifluoromethyl anthranilonitrile (12.2 g) in 50 ml of nitrobenzene was added freshly fused and pulverized zinc chloride (13.4 g). This was stirred at 50° C. for 1.5 hours after which was added tetrahydrothiopyran-4-one (9.9 g). The reaction mixture was stirred at 130° C. for 2 hours and allowed to cool, and the resulting complex was filtered and rinsed with ethyl ether. The solid was partitioned between 2-butanone (MEK) and NH4OH and the aqueous phase was extracted with MEK (2x). The organics were washed with water, dried (saturated NaCl, MgSO4) and concentrated to give 10.2 g of a yellow powder m.p. 253°-259° C.d. A 3.7 g portion was recrystallized from methanol/water to give 3.0 g of an off-white powder, m.p. 258°-262° C. d.

1. stirringThe reaction mixture was stirred at 130° C. for 2 hours
2. temperatureto cool
3. filtrationthe resulting complex was filtered
4. washrinsed with ethyl ether
5. customThe solid was partitioned between 2-butanone (MEK) and NH4OH
6. extractionthe aqueous phase was extracted with MEK (2x)
7. washThe organics were washed with water
8. dry with materialdried (saturated NaCl, MgSO4)
9. concentrationconcentrated