反应详情

1 g of 3-formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine is dissolved in 150 ml methanol, and excess sodium boro hydride is added in small portions at room temperature. After reduction has been completed, 150 ml icewater is added. The volatile components are evaporated in the rotary evaporator in vacuo. Subsequently extraction is carried out 3×with 40 ml ethyl acetate each time. The combined extracts are stripped off in vacuo of solvents, and the crystalline residue is recrystallized from methanol. The title compound of 192°-193° C. is obtained.

1. addition150 ml icewater is added
2. customThe volatile components are evaporated in the rotary evaporator in vacuo
3. extractionSubsequently extraction
4. customthe crystalline residue is recrystallized from methanol