HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-Formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (1R,2R)-2-bromo-2,3-dihydro-1H-inden-1-ol | HCID 820607 | — |
| Reactant | 3-Formyl-8-hydroxy-2-methylimidazo[1,2-a]pyridine | HCID 23294187 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 3-Formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine | HCID 22843825 | — |
Reaction Steps
A mixture of 4.4 g (25 mmol) 3-formyl-8-hydroxy-2-methyl-imidazo[1,2-a]pyridine, 10.7 g (50 mmol) (trans)-2-bromo-1-indanol and 13.8 g of potassium carbonate is stirred in 120 ml of methanol/water (4:1) for 16 hours at 40° C. The mixture is worked up analogously to Example 21 and the yield of the title compound m.p. 200°-202° C. (from methanol) is 4.8 g (62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112834 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-549eaca735cf47ca9d7089df27aa2ed4 |
| Source note | uspto-grants-1992_05 |