HCID 67772040, compound → HCID 67772079, compound

HRID 1195736Notes

Reaction equation

HRID 1195736 reaction equation
[BrH:1].[CH3:2][C:3]1[N:4]=[C:5]2[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][N:6]2[CH:14]=1.[H][H]>CO.[Pd]>[BrH:1].[NH2:11][C:10]1[C:5]2[N:6]([CH:14]=[C:3]([CH3:2])[N:4]=2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 67772040HCID 67772040, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67772079HCID 67772079, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 16.5 g 2-methyl-8-nitro-imidazo[1,2-a]pyridine-hydrobromide in 800 ml methanol is saturated with hydrogen at room temperature at low pressure for 8 hours after addition of a catalytic amount of commercial Pd/C-catalyst. The catalyst is then filtered off and the filtrate evaporated until dry. After recrystallization from acetronitrile 11.9 g of the title compound of m.p. 237°-238° C. is obtained.

Workup

  1. filtrationThe catalyst is then filtered off
  2. customthe filtrate evaporated
  3. customuntil dry
  4. customAfter recrystallization from acetronitrile 11.9 g of the title compound of m.p. 237°-238° C.
  5. customis obtained

Sources & evidence

ORD record
ord-896263740a794253aeb61a172c9119bd
Source dataset
uspto-grants-1992_05
Patent number
US05112834

Reaction notes

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