反应详情

20.0 g of 2-amino-3-nitropyridine and 22 g of bromoacetone are boild in 1 l ethanol for 55 hours under reflux. The mixture is then cooled in an icebath, the crystalline hydrobromide filtered off under suction and washed with ethanol. After drying in a vacuum at 50° C. the yield of the title compound of m.p. 300° C. (decomposition) is 17.2 g.

1. customfor 55 hours
2. temperatureunder reflux
3. temperatureThe mixture is then cooled in an icebath
4. filtrationthe crystalline hydrobromide filtered off under suction
5. washwashed with ethanol
6. dry with materialAfter drying in a vacuum at 50° C. the yield of the title compound of m.p. 300° C. (decomposition)