Hydrogen Bromide → HCID 54507242, compound

Participants

Reaction Steps

A mixture of 0.5 g 8-benzyloxy-6-chloro-3-formyl-2-methyl-imidazo[1,2-a]pyridine, 2.5 ml acetic acid and 2.5 ml 48% aqueous hydrogen bromide solution is heated under reflux for 2 hours. The mixture is cooled to room temperature, poured over 50 ml icewater, neutralized with 1 N-sodium hydroxide solution and extracted 3×with 20 ml ethyl acetate each time. The combined extracts are dried over sodium sulfate, the solvent is stripped off and the solid residue is recrystallized from dioxane. 0.2 g of the title compound of m.p. 256° C. (decomposition) is obtained.

Provenance & Evidence