Dimethylformamide → HCID 53927534, compound

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A mixture of 6-nitro-2-phenyl-1,2,3,4-tetrahydroquinoline-4,8-dicarboxylic acid (8.92 g), potassium carbonate (10 g) and methyl iodide (5 ml) in DMF (30 ml) was stirred at room temperature for 2 hours, filtered and concentrated. The residue was dissolved in ethyl acetate (300 ml). The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated to give 7.92 g (82.3%) of the title compound as yellow crystals.

Provenance & Evidence