Sodium Hydroxide → HCID 15157756, compound

HRID 1195750Notes

Reaction equation

HRID 1195750 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([C:14]([OH:16])=[O:15])[CH:13]=1)[NH:10][CH2:9][CH2:8][CH:7]2[C:17]([OH:19])=[O:18])(=[O:3])N.[OH-:20].[Na+]>>[NH:10]1[C:11]2[C:6](=[CH:5][C:4]([C:1]([OH:20])=[O:3])=[CH:13][C:12]=2[C:14]([OH:16])=[O:15])[CH:7]([C:17]([OH:19])=[O:18])[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 15157755HCID 15157755, compound

Product 1

HCID 15157756HCID 15157756, compoundYield 72.9%

Procedure

A solution of 6-carbamoyl-1,2,3,4-tetrahydroquinoline-4,8-dicarboxylic acid (1.77 g) in 10% aqueous sodium hydroxide solution (20 ml) was refluxed for 10 hours and after cooling, adjusted to pH 1. The resulting precipitate was collected by filtration, washed with water and dried to give the title compound (1.29 g, 72.9%) which was recrystallized from ethanol to white crystals, mp 240° C.-241° C.

Workup

  1. temperatureafter cooling, adjusted to pH 1
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-555e5492978b4f79b2efc735fa7c67a4
Source dataset
uspto-grants-1992_05
Patent number
US05112836

Reaction notes

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