Potassium tert-butoxide → HCID 54147898, compound

Participants

Reaction Steps

To a solution of methyl [(9-amino-1,2,3,4-tetrahydroacridin-1-yl)thio]acetate (10.3 g) in tetrahydrofuran (150 ml) was added potassium t-butoxide (4.6 g). The reaction mixture was stirred at ambient temperature for 45 mins and then concentrated. The residue was stirred in water, the solid was collected, and dried. The solid was purified by flash chromatography (ethyl acetate/dichloromethane→5% methanol/dichloromethane) to give 4.1 g (44%) of product, mp 223°-226° C. (dec.). Recrystallization from methanol gave the analytical sample, mp 223.5°-226° C. (dec.).

Provenance & Evidence