反应详情

8-Methoxy-1,2,3,4-tetrahydro-9-acridinamine (4.0 g) was dissolved in dichloromethane (76 ml). Boron tribromide in dichloromethane (15.0 ml of a 1.0M solution) was added, and the reaction mixture was stirred 1 hr and then concentrated under reduced pressure. The residue was dissolved in warm water (100 ml), concentrated hydrochloric acid (400 ml) was added and the solution was chilled overnight in the refrigerator. The salt was collected and recrystallized from methanol-ether to give 2.68 g (61%) of product, mp 270° C. (dec).

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in warm water (100 ml)
3. additionconcentrated hydrochloric acid (400 ml) was added
4. temperaturethe solution was chilled overnight in the refrigerator
5. customThe salt was collected
6. customrecrystallized from methanol-ether