HCID 14857312, compound → HCID 14857388, compound

HRID 1195815Notes

Reaction equation

HRID 1195815 reaction equation
[CH3:1][C:2]1([CH3:28])[CH:11]([OH:12])[CH:10]([C:13]2[C:14](=[O:26])[N:15](CC3C=CC=CC=3)[CH:16]=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7](Br)[CH:8]=2)[O:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:28])[CH:11]([OH:12])[CH:10]([C:13]2[C:14](=[O:26])[NH:15][CH:16]=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[O:3]1

Participants

4

Reactant 1

HCID 14857312HCID 14857312, compound

Product 1

HCID 14857388HCID 14857388, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 280 mg of 2,2-dimethyl-4-(1-benzyl-1,2-dihydro-2oxo-3pyridyl)-6-bromo-3-chromanol is hydrogenated on 140 mg of 20% Pd-C in 80 ml of methanol at 20° and 1 bar, the mixture is filtered, the filtrate is evaporated and 2,2-dimethyl-4-(1,2-dihydro-2-oxo-3-pyridyl)-3-chromanol, m.p. 244°-246°, is obtained after chromatographic purification on silica gel.

Workup

  1. filtration1 bar, the mixture is filtered
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-eb2b447304014593ab873f0a4e20592d
Source dataset
uspto-grants-1992_05
Patent number
US05112839

Reaction notes

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