Phosphoric Acid → HCID 54501164, compound

HRID 1195816Notes

Reaction equation

HRID 1195816 reaction equation
[CH3:1][C:2]1([CH3:29])[CH:11]([OH:12])[CH:10]([C:13]2[C:14](=[O:26])[N:15]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:16]=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:27]#[N:28])[CH:8]=2)[O:3]1.P(=O)(O)(O)[OH:31]>>[CH3:1][C:2]1([CH3:29])[CH:11]([OH:12])[CH:10]([C:13]2[C:14](=[O:26])[N:15]([CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:16]=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:27](=[O:31])[NH2:28])[CH:8]=2)[O:3]1

Participants

3

Reactant 2

HCID 1004Phosphoric AcidHCID 14857308HCID 14857308, compound

Product 1

HCID 54501164HCID 54501164, compound

Procedure

A mixture of 1 g of 2,2-dimethyl-4-(1-benzyl-1,2-dihydro-2-oxo-3-pyridyl)-6-cyano-3-chromanol and 10 ml of 85 percent phosphoric acid is warmed to 100° for 2 hours. After cooling and working up in the customary manner, there is obtained 2,2-dimethyl-4- (1-benzyl-1,2-dihydro-2-oxo-3-pyridyl)-6-carbamoyl -3-chromanol, m.p. 230°-235°.

Workup

  1. temperatureis warmed to 100° for 2 hours
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-d3ead71a390b434f989a22c21abfc819
Source dataset
uspto-grants-1992_05
Patent number
US05112839

Reaction notes

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