Sodium Bicarbonate → HCID 86745775, compound

Participants

Reaction Steps

A mixture of 6-cyano-2methyl-4-quinolone (9.2 g, Chem. Abs., 51, 11347h; known therein as 6-cyano-4-hydroxyquinaldine), Raney nickel (10 g) and 75% formic acid (150 ml ) was heated at reflux for 3 hours. The mixture was cooled, neutralised with a saturated aqueous solution of sodium bicarbonate and filtered. The solid residue was washed with warm methanol (3×50 ml). The combined filtrates were extracted with ethyl acetate (3×50 ml). The combined extracts were washed with water (100 ml), dried over sodium sulphate and evaporated to give 6-formyl-2-methyl-4-quinolone as a fawn coloured solid (9.3 g).

Provenance & Evidence