Formaldehyde → HCID 57225421, compound

HRID 1195828Notes

Reaction equation

HRID 1195828 reaction equation
[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([CH2:11][NH:12][CH2:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[CH2:24]=O.[OH-].[Na+]>O1CCOCC1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([CH2:11][N:12]([CH3:24])[CH2:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)=[CH:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 86744069HCID 86744069, compound

Product 1

HCID 57225421HCID 57225421, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.8 g of N-(4-tert.butyl-1-cyclohexenylmethyl)-1-naphthylmethylamine are reacted with 13 ml of 1N NaH2PO3 -solution and brought into solution by the addition of 15 ml of dioxane. Following addition of 1.1 ml 37% formaline solution the mixture is warmed to 60° for 1/2 hour, made alkaline with caustic soda and extracted with ether. Following drying and evaporation of the organic phase the pure product is obtained as an oil.

Workup

  1. temperatureis warmed to 60° for 1/2 hour
  2. extractionextracted with ether
  3. customFollowing drying
  4. customevaporation of the organic phase the pure product
  5. customis obtained as an oil

Sources & evidence

ORD record
ord-5896cff8143a4ddea63203bf0663bc10
Source dataset
uspto-grants-1992_05
Patent number
US05112851

Reaction notes

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