HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethenesulfonyl fluoride → N-[2-(Fluorosulfonyl)ethyl]-3,4-dimethoxy-N-methylphenethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethenesulfonyl fluoride | HCID 69612 | — |
| Reactant | N-Methylhomoveratrylamine | HCID 77039 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[2-(Fluorosulfonyl)ethyl]-3,4-dimethoxy-N-methylphenethylamine | HCID 54276374 | 11% |
Reaction Steps
The reaction between 3,4-dimethoxy-N-methylphenethylamine (15 mmol) and ethenesulfonyl fluoride (1.65 mL, 19 mmol) was carried out in DMF (30 mL) at ambient temperature for 3 hours as described in Example 16. There was obtained an orange liquid which was crystallized from ether/methanol to afford the title compound as a yellow solid (0.14 g, 11% yield), mp 200°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112866 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-148cfe2c30c64190a703affad1b22852 |
| Source note | uspto-grants-1992_05 |