HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1195943Generated: November 1, 2026
Nitric Acid → 1-(4-Hydroxy-3-methoxy-5-nitrophenyl)ethanone
https://huagongshe.com/reaction/1195943
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Acetovanillone | HCID 2214 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(4-Hydroxy-3-methoxy-5-nitrophenyl)ethanone | HCID 294764 | — |
Reaction Steps
To a solution containing 40 ml of nitric acid (d=1.41) and 40 ml of water was gradually added while cooling (below 7° C.) and stirring 25.0 g of 4'-hydroxy-3'-methoxyacetophenone. After stirring for 0.5 h at 0° C. the product was filtered, washed first with diluted nitric acid (1:1) and then with water. Yield 24.0 g (75%). The 1H-NMR-spectrum of the product was in accordance with the structure alleged.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05112861 |
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| Source dataset | uspto-grants-1992_05 |
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| ORD ID | ord-0d6fa06d5ebb4065b9a1c625cb7077fd |
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| Source note | uspto-grants-1992_05 |
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