HCID 22125755, compound → HCID 18990339, compound

HRID 1195949Notes

Reaction equation

HRID 1195949 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[OH:8]>S(Cl)(Cl)=O>[CH:6]([NH:9][C:16](=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12][C:4]1[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]([OH:8])=[C:2]([OH:1])[CH:3]=1)([CH3:7])[CH3:5]

Participants

3

Reactant 1

HCID 22125755HCID 22125755, compound

Product 1

HCID 18990339HCID 18990339, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Conditions

Temperature
20 °C

Procedure

A solution containing 0.5 g of the product obtained in Example 24 in 2.5 ml of thionyl chloride was refluxed for 10 min. The excess of thionyl chloride was evaporated in vacuo and the residue dissolved in 25 ml of dichloromethane. To this solution 0.47 g of isopropylamine was added and the mixture was stirred for 1 h at 20° C. Dichloromethane phase was washed with 1 N hydrochloric acid and evaporated in vacuo. The residue was crystallized from toluene. Yield 0.44 g (75%), m.p. 113°-115° C.

Workup

  1. temperaturewas refluxed for 10 min
  2. customThe excess of thionyl chloride was evaporated in vacuo
  3. dissolutionthe residue dissolved in 25 ml of dichloromethane
  4. additionTo this solution 0.47 g of isopropylamine was added
  5. washDichloromethane phase was washed with 1 N hydrochloric acid
  6. customevaporated in vacuo
  7. customThe residue was crystallized from toluene

Sources & evidence

ORD record
ord-39550bdd1b8049bcba8079da628b238a
Source dataset
uspto-grants-1992_05
Patent number
US05112861

Reaction notes

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