反应详情

To a solution containing 10.0 g 3,4 dimethoxy-6-chlorobenzaldehyde and 8 ml of ethyl crotonate in 60 ml of N-methylpyrrolidone 6.0 g of potassium tert.-butoxide was added while stirring. The solution was stirred for 0.5 h more at 20° C. and poured then to a mixture of ice and hydrochloric acid. The solution was extracted with ether. The ether solution was washed with water and extracted with 2.5 N NaOH-solution. The aqueous phase was acidified with hydrochloric acid and the semisolid product was separated. Yield 10.8 g (81%).

1. additionwas added
2. stirringThe solution was stirred for 0.5 h more at 20° C.
3. additionpoured
4. extractionThe solution was extracted with ether
5. washThe ether solution was washed with water
6. extractionextracted with 2.5 N NaOH-solution
7. customthe semisolid product was separated