反应详情

温度

20 °C

To a solution containing 0.54 g of the product obtained in Example 35 in 6 ml dichloromethane 6 ml of 1 molar boron tribromide-dichloromethane solution was added and stirred for 24 h at 20° C. The solvent was evaporated in vacuo and 2 N hydrochloric acid was added to the residue. The product was filtered and washed with water. Recrystallization from isopropanol-water yielded 0.22 g (46%) of the product desired, m.p. 203°-206° C.

1. additionwas added
2. customThe solvent was evaporated in vacuo and 2 N hydrochloric acid
3. additionwas added to the residue
4. filtrationThe product was filtered
5. washwashed with water
6. customRecrystallization from isopropanol-water