HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(3,4-Dihydroxy-5-nitrophenyl)-1-(4-methylphenyl)prop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Phenyl-1-propanone | HCID 7148 | — |
| Reactant | 1-(4-Hydroxy-3-methoxy-5-nitrophenyl)ethanone | HCID 294764 | — |
| Reactant | 3,4-Dihydroxy-5-nitrobenzaldehyde | HCID 5748957 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3,4-Dihydroxy-5-nitrophenyl)-1-(4-methylphenyl)prop-2-en-1-one | HCID 53989990 | — |
Reaction Steps
A solution containing 5.49 g of 3,4-dihydroxy-5-nitrobenzaldehyde and 5.37 g of 4,-methylacetophenone in 50 ml of tetrahydrofuran was added a catalytic amount of gaseous hydrogen chloride and refluxed for 4.5 h. The solvent was evaporated in vacuo and the residue crystallized from ether-petroleum-ether, yield 1.85 g (21%), m.p. 184°-186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112861 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-0a1415816a7c4d128fab40b22bc537a9 |
| Source note | uspto-grants-1992_05 |