Water → HCID 18990404, compound

HRID 1195959Notes

Reaction equation

HRID 1195959 reaction equation
[C:1]12([NH:11][C:12](=[O:30])[C:13]3[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[C:16]([O:22]C(=O)C)=[C:15]([O:26]C(=O)C)[CH:14]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.S(=O)(=O)(O)O.O>CO>[C:1]12([NH:11][C:12](=[O:30])[C:13]3[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[C:16]([OH:22])=[C:15]([OH:26])[CH:14]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 19389229HCID 19389229, compound

Product 1

HCID 18990404HCID 18990404, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution containing 1.2 g of the product obtained in Example 43 and a catalytic amount of sulfuric acid in 10 ml of methanol was refluxed for 3 h. 20 ml of water was added and on cooling 0.85 g (89.5%) of the desired product was crystallized, m.p. 207°-208° C.

Sources & evidence

ORD record
ord-3e2095528a7747e08d6cff10aec251c5
Source dataset
uspto-grants-1992_05
Patent number
US05112861

Reaction notes

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