Hydrochloric Acid → 1-Phenyl-3-(3,4-dihydroxy-5-trifluoromethylphenyl)prop-2-en-1-one

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Reaction Steps

To a solution containing 0.32 g of the above product obtained in Example 85 in 10 ml of dichloromethane 3 ml of 1 molar BBr3 --CH2Cl2 was added. The mixture was stirred for 20 min at room temperature, acidified with 10 ml 2 N hydrochloric acid and extracted with dichloromethane. The solvent was evaporated in reduced pressure and the residue crystallized from acetone-dichloromethane. Yield 0.07 g (23%), m.p. 196°-201° C.

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