HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Formyl-2,3-dimethoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 3-Bromo-4,5-dimethoxybenzaldehyde | HCID 81379 | — |
| Product | 5-Formyl-2,3-dimethoxybenzonitrile | HCID 19041810 | — |
Reaction Steps
A mixture containing 2.5 g of 3,4-dimethoxy-5-bromobenzaldehyde and 1.0 g of cuprous cyanide in N-methylpyrrolidone was refluxed for 2 h. Water was added and the solution was extracted with dichloromethane. The solvent was evaporated in vacuo. Yield 1.55 g (81%), m.p. 109°-112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112861 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-264ad032d80a45cbbe8cd8a6d7c41c70 |
| Source note | uspto-grants-1992_05 |