Phosphorus tribromide → HCID 15173705, compound

HRID 1195992Notes

Reaction equation

HRID 1195992 reaction equation
C([O:4][C:5]1[C:13]([O:14]C)=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[C:16]#[N:17])(=O)C.P(Br)(Br)Br>ClCCl>[OH:14][C:13]1[CH:12]=[C:8]([CH:7]=[C:6]([C:16]#[N:17])[C:5]=1[OH:4])[C:9]([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 19389202HCID 19389202, compound

Product 1

HCID 15173705HCID 15173705, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution containing 2.3 g of 4-acetoxy-3-cyano-5-methoxybenzoic acid in 10 ml of dichloromethane 40 ml of 1 molar PBr3 in dichloromethane was added. The mixture was stirred over night at room temperature. The solvent was evaporated in vacuo and to the residue ice-water was added. The product was filtered and washed with water. Yield 1.25 g (74%), m.p. 269°-271° C.

Workup

  1. additionwas added
  2. customThe solvent was evaporated in vacuo and to the residue ice-water
  3. additionwas added
  4. filtrationThe product was filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-28a3911989294d80b05629b872d602ce
Source dataset
uspto-grants-1992_05
Patent number
US05112861

Reaction notes

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