Dimethylamine → HCID 54149543, compound

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Reaction Steps

3-Bromo-N-octylpropanamide (21.3 g) was dissolved in ethanol (50 ml) and a 33% solution of dimethylamine in IMS (100 ml) was added. The solution was allowed to stand at 20° for 72 hours then evaporated to give a yellow oil. This oil was dissolved in dilute HCl to give a solution of pH 4 which was washed twice with dichloromethane, basified with dilute aqueous sodium hydroxide solution and extracted with dichloromethane three times. The latter dichloromethane extracts were dried and evaporated to a pale yellow oil. Distillation of the residue gave 3-dimethylamino-N-octylpropanamide as a colourless oil (15.1 g, 83% yield) (bp 135°-8°/0.15mm).

Provenance & Evidence