Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (1-Benzylindazol-3-yl)methanol | HCID 10657568 | — |
| Product | (+-)-2-Hydroxy-2-methylbutyric acid | HCID 95433 | — |
| Product | (1-Benzylindazol-3-yl)methanol | HCID 10657568 | — |
Reaction Steps
A solution of 6 ml of chloroform and of 6,8 ml of methyl ethyl ketone is added dropwise in about 30 minutes to a suspension of 5.9 g of 1-benzyl-3-hydroxymethyl-indazole, prepared as described above, of 12 g of NaOH and of 35 ml of methyl ethyl ketone. When the addition is over, the reaction mixture is heated to reflux. After 60 minutes, the reaction mixture is cooled, water is added and the aqueous phase is separated and acidified. The resulting oil is extracted with diethyl ether and the solvent is evaporated to give an oil that hardens and is crystallized from hexane/ethyl acetate 1:1; the ether of 1-benzyl-3-hydroxymethyl-indazole with 2-hydroxy-2-ethyl-propionic acid is thus obtained (Compound I, R=CH3, R'=C2H5, R'"=H), m.p. 115°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05112986 |
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| Source dataset | uspto-grants-1992_05 |
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| ORD ID | ord-680699e9a7b54d99b98ab7be9ed453c4 |
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| Source note | uspto-grants-1992_05 |
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