HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 14989574, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | p-Fluorophenyl 4-piperidyl ketone hydrochloride | HCID 3084438 | — |
| Reactant | HCID 14989573 | HCID 14989573 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 14989574 | HCID 14989574 | 63.6% |
Reaction Steps
A mixture of N-[1-(1,6-dihydro-6-oxo-3-pyridinyl)cyclohexyl]chloroacetamide (1.74 g), 4-(4-fluorobenzoyl)piperidine hydrochloride (1.57 g) and diisopropylethylamine (1.67 g) was heated in 35 ml of refluxing acetonitrile for 1 hour. The resulting suspension was cooled to room temperature and the solid was collected, yielding 1.8 g of solid. Recrystallization from methanol gave 1.1 g of product as a solid, m.p. 243°-245° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112981 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-050f638b1efb4d86824306250f16231a |
| Source note | uspto-grants-1992_05 |