Hydrochloric Acid → L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1)

Participants

Reaction Steps

The same esterification procedure as in Example 1 was followed with the exception that the L-phenylalanine was replaced with 133.1 g of L-aspartic acid and that 133.1 g of methanol and 64 g of hydrochloric acid were used. Following cooling to deposit the crystals, the latter were collected by filtration and then dried to obtain 160.5 g (78.4 yield) of L-aspartic acid dimethyl ester hydrochloride having a purity of 96.5% and containing 0.2% of water and 2.6% of the total of L-aspartic acid and α- and β-monomethyl esters of L-aspartic acid.

Provenance & Evidence