Hydrochloric Acid → L-phenylalanine methyl ester sulfate

Participants

Reaction Steps

The same esterification procedure as in Example 1 was followed with the exception that 165.2 g of L-phenylalanine and 165.2 g of methanol were used and that the hydrochloric acid was replaced with 120.1 g of 98% sulfuric acid. The reaction was conducted at 60° C. for 8 hours, followed by cooling in order to deposit the crystals, which were collected by filtration and then dried to obtain 184.9 g (63.8% yield) of L-phenylalanine methyl ester sulfate having a purity of 95.7% and containing 0.3% of water and 2.4% of L-phenylalanine.

Provenance & Evidence