反应详情

A solution of (3S,4S)-4-(1-carboxyethenyl)-3-(1-(R)-benzyloxycarbonyloxyethyl)-1-di(p-anisyl)methyl-2-azetidinone (3.7 g) in acetone (60 ml) was treated with benzyl bromide (1.4 g) in the presence of anhydrous potassium carbonate (1.88 g) under reflux for 2 hours. The reaction mixture was cooled down to room temperature, filtered to remove insoluble materials and concentrated in vacuo. The concentrate was diluted with ethyl acetate, washed with water and dried over anhydrous sodium sulfate. Filtration and concentration of the filtrate in vacuo gave (3S,4S)-4-(1-benzyloxycarbonylethenyl)-3-(1-(R)-benzyloxycarbonyloxyethyl)-1-di(p-anisyl)methyl-2-azetidinone.

1. temperatureunder reflux for 2 hours
2. filtrationfiltered
3. customto remove insoluble materials
4. concentrationconcentrated in vacuo
5. additionThe concentrate was diluted with ethyl acetate
6. washwashed with water
7. dry with materialdried over anhydrous sodium sulfate
8. filtrationFiltration and concentration of the filtrate in vacuo