HCID 53670160, compound → HCID 53903373, compound

HRID 1196225Notes

Reaction equation

HRID 1196225 reaction equation
[CH3:1][C:2]([CH3:34])([O:4][C:5]([NH:7][CH2:8][C:9]1[N:14]=[C:13]([C:15]([OH:17])=[O:16])[CH:12]=[C:11]([O:18]CC2C=CC=CC=2)[C:10]=1[O:26]CC1C=CC=CC=1)=[O:6])[CH3:3]>CO.[Pd]>[CH3:3][C:2]([CH3:34])([O:4][C:5]([NH:7][CH2:8][C:9]1[NH:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][C:11](=[O:18])[C:10]=1[OH:26])=[O:6])[CH3:1]

Participants

4

Reactant 1

HCID 53670160HCID 53670160, compound

Product 1

HCID 53903373HCID 53903373, compoundYield 82.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3.94 g 6-[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-4,5-bis(phenylmethoxy)-2-pyridinecarboxylic acid and 1.3 g palladium/carbon (10%) were suspended in 70 ml methanol. Hydrogenation at normal pressure completed the reaction after one hour. The catalyst was then filtered off and washed with dimethylformamide. The combined filtrates were evaporated and the residue stirred with ether. 2 g of title compound were obtained as a white powder. M.P.=>300° C.

Workup

  1. customthe reaction after one hour
  2. filtrationThe catalyst was then filtered off
  3. washwashed with dimethylformamide
  4. customThe combined filtrates were evaporated

Sources & evidence

ORD record
ord-b281e99df3d3448db830fe6c28151a7f
Source dataset
uspto-grants-1992_05
Patent number
US05112968

Reaction notes

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