Hydrochloric Acid → 136916-30-8

Participants

Reaction Steps

7,7-Diphenyl-2-vinyloxycarbonyl-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-one (2.6 g) is stirred in a 3N solution (30 cc) of hydrogen chloride in dioxane at room temperature for 30 minutes; the mixture is concentrated to dryness under reduced pressure (2.7 kPa). The residue is taken up with ethanol (50 cc) and heated to reflux for 30 minutes; the mixture is concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallized in ethyl ether (20 cc); the crystals obtained are drained and dried. 7,7-Diphenyl-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-one hydrochloride (2 g), m.p. above 260° C., is obtained.

Provenance & Evidence