Potassium Carbonate → HCID 54361557, compound

Participants

Reaction Steps

Trifluoroacetic acid (2 drops) is added to a solution of 4,4-diphenyl-2,5-cyclohexadien-1-one (7.7 g) and N-butoxymethyl-N-(trimethylsilylmethyl)benzylamine (11 cc) in dry dichloromethane (80 cc), and the reaction mixture is heated to reflux for 1 hour and a half. A further portion (5 cc) of N-butoxymethyl-N-(trimethylsilylmethyl)benzylamine is added as well as trifluoroacetic acid (2 drops), and the reaction mixture is heated for 1 hour and a half. The reaction mixture is heated with potassium carbonate (3 g), filtered and concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallized in isopropyl ether (15 cc). The crystals obtained are drained, washed with isopropyl ether (2×5 cc) and dried; (3aRS,7aRS)-2-benzyl-7,7-diphenyl-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-one (4.4 g), m.p. 132° C., is obtained.

Provenance & Evidence