Methane → 7,7-Bis(2-fluorophenyl)perhydro-4-isoindolone hydrochloride

Participants

Reaction Steps

A solution of (3aRS,7aRS)-2-benzyl-7,7-bis(2-fluorophenyl)perhydro-4-isoindolone (2.34 g) in methanol (100 cc), to which N hydrochloric acid (6.2 cc) is added, is hydrogenated at atmospheric pressure in the presence of palladinized charcoal (10% palladium) (0.4 g) for 5 hours at 25° C. The reaction medium is filtered and concentrated under reduced pressure (2.7 kPa) to give (3aRS,7aRS)-7,7-bis(2-fluorophenyl)perhydro-4-isoindolone hydrochloride (2 g) in the form of a white solid.

Provenance & Evidence