Hydrochloric Acid → HCID 67916022, compound

Participants

Reaction Conditions

Reaction Steps

(3aRS,7aRS)-7,7-Bis(3-chlorophenyl)-2-vinyloxycarbonylperhydro-4-isoindolone (1.5 g) is treated with a 6N solution (7.4 cc) of hydrochloric acid in dioxane for 2 hours at 25° C. The solution is concentrated to dryness under reduced pressure (2.7 kPa) and the residue is heated for 1 hour in solution in ethanol at 60° C. and then stirred for 6 hours at 25° C. The solution is concentrated to dryness under reduced pressure (2.7 kPa) and the meringue-like product obtained solidified in isopropyl ether. The precipitate is drained and washed with isopropyl ether, then dried to give 7,7-bis(3-chlorophenyl)perhydro-4-isoindolone hydrochloride (1 g).

Provenance & Evidence