Hydrochloric Acid → HCID 67915919, compound

Participants

Reaction Conditions

Reaction Steps

(3aRS,7aRS)-7,7-Bis(3-tolyl)-2-vinyloxycarbonylperhydro-4-isoindolone (7.4 g) is treated with a 6N solution (39 cc) of hydrochloric acid in dioxane for 30 minutes at 25° C. The solution is concentrated to dryness under reduced pressure (2.7 kPa) and the residue taken up with ethanol (100 cc). The solution is heated to 60° C. for 2 hours and stirred for 16 hours at 25° C., then concentrated to dryness under reduced pressure (2.7 kPa). The residue is solidified with isopropyl ether and the solid is washed, drained and dried. 7,7-Bis(3-tolyl)perhydro-4-isoindolone hydrochloride (6.36 g) is obtained in the form of a yellow solid.

Provenance & Evidence