Hydrochloric Acid → HCID 67915940, compound

Participants

Reaction Steps

(3aRS,7aRS)-2-[(2-tert-Butoxycarbonylaminophenyl)acetyl]-7,7-diphenylperhydro-4-isoindolone (1.5 g) is treated with a 5.7N solution (15 cc) of hydrochloric acid in dry dioxane at 20° C. for 4 hours. The reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) and the residue purified by dissolution in acetonitrile (20 cc) and precipitation with isopropyl ether (30 cc). The solid is drained, washed with isopropyl ether and dried. (3aRS,7aRS)-2-[(2-Aminophenyl)acetyl]-7,7-diphenylperhydro-4-isoindolone hydrochloride (1.1 g) is obtained in the form of a slightly pinkish solid.

Provenance & Evidence