HCID 178462340, compound → HCID 178476377, compound

HRID 1196293Notes

Reaction equation

HRID 1196293 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:14]([N:16]1[CH2:44][CH2:43][CH2:42][C@H:17]1[C:18]([NH:20][C@H:21]([C:32]([O:34]CC1C=CC=CC=1)=[O:33])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:31])[NH:27][N+]([O-])=O)=[O:19])=[O:15])[C@@H:11]([CH3:13])[OH:12])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]>[C].[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:14]([N:16]1[CH2:44][CH2:43][CH2:42][C@H:17]1[C:18]([NH:20][C@H:21]([C:32]([OH:34])=[O:33])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:27])[NH2:31])=[O:19])=[O:15])[C@@H:11]([CH3:13])[OH:12])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].[CH3:21][C:32]([OH:34])=[O:33]

Participants

3

Reactant 1

HCID 178462340HCID 178462340, compound

Product 1

HCID 178476377HCID 178476377, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

150 mg of Z-Asn-Thr-Pro-Arg(NO2)-OBzl was reduced in the presence of palladium-carbon in the same manner as in Example 7-(4). The resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase), subjected to Dowex 1×2 (acetate type) treatment and freeze-dried to obtain the desired compound.

Workup

  1. customThe resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase)
  2. customfreeze-dried

Sources & evidence

ORD record
ord-5b921bd273e4458a96520c140d16c45d
Source dataset
uspto-grants-1992_05
Patent number
US05112947

Reaction notes

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