HCID 178462154, compound → HCID 178476376, compound

HRID 1196296Notes

Reaction equation

HRID 1196296 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:42][CH2:41][CH2:40][C@H:15]1[C:16]([NH:18][C@H:19]([C:30]([O:32]CC1C=CC=CC=1)=[O:31])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:29])[NH:25][N+]([O-])=O)=[O:17])=[O:13])[CH3:11])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]>[C].[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:42][CH2:41][CH2:40][C@H:15]1[C:16]([NH:18][C@H:19]([C:30]([OH:32])=[O:31])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:25])[NH2:29])=[O:17])=[O:13])[CH3:11])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].[CH3:19][C:30]([OH:32])=[O:31]

Participants

3

Reactant 1

HCID 178462154HCID 178462154, compound

Product 1

HCID 178476376HCID 178476376, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

150 mg of Z-Asn-Ala-Pro-Arg(NO2)-OBzl was reduced in the presence of palladium-carbon in the same manner as in Example 7-(4). The resulting product was purified by high-performance liquid chromatography at 12 ml/min.(flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase), subjected to Dowex 1×2 (acetate type) treatment and freeze-dried to obtain the desired compound.

Workup

  1. customThe resulting product was purified by high-performance liquid chromatography at 12 ml/min.(flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase)
  2. customfreeze-dried

Sources & evidence

ORD record
ord-be2fafb2a387400f8021bf5ef745668f
Source dataset
uspto-grants-1992_05
Patent number
US05112947

Reaction notes

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