1,1-Dimethylethyl (2R)-2-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)-1-pyrrolidinecarboxylate → Boc-D-Pro-Arg(NO2)-OBzl

HRID 1196297Notes

Reaction equation

HRID 1196297 reaction equation
[NH2:1][C@H:2]([C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10].[N:23]1([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH2:37][CH2:36][CH2:35][C@@H:24]1[C:25](ON1C(=O)CCC1=O)=[O:26]>>[N:23]1([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH2:37][CH2:36][CH2:35][C@@H:24]1[C:25]([NH:1][C@H:2]([C:13]([O:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10])=[O:26]

Participants

3

Reactant 2

HCID 8538841,1-Dimethylethyl (2R)-2-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)-1-pyrrolidinecarboxylateHCID 178512187HCID 178512187, compound

Product 1

HCID 178451950Boc-D-Pro-Arg(NO2)-OBzl

Procedure

The desired compound was prepared as an oily product from 9 g of H-Arg(NO2)-OBzl and 9 g of Boc-D-Pro-OSu in the same manner as in Example 7-(1).

Sources & evidence

ORD record
ord-255337f4a2d4424e929d3a6f424b814e
Source dataset
uspto-grants-1992_05
Patent number
US05112947

Reaction notes

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