反应详情

A 500 mL flask was charged with 25.5 g (120 mmol) of trans-2-bromo-1-indanol, 1 g of toluenesulfonic acid and 350 mL of toluene. This was capped with a Dean-Stark trap and heated to reflux for two hours at which time the system was cooled to room temperature and the volatiles removed in vacuo to leave a dark oil. The residue was taken up into hexanes and eluted through a silica pad using hexanes. Removal of the volatiles in vacuo gave 22.5 g (96 percent) of a light yellow oil.

1. customThis was capped with a Dean-Stark trap
2. temperatureheated
3. temperatureto reflux for two hours at which time the system
4. customthe volatiles removed in vacuo
5. customto leave a dark oil
6. washeluted through a silica pad
7. customRemoval of the volatiles in vacuo