HCID 178512169, compound → HCID 178476717, compound

HRID 1196301Notes

Reaction equation

HRID 1196301 reaction equation
[N:1]1(C(OCC2C=CC=CC=2)=O)[CH2:50][CH2:49][CH2:48][C@H:2]1[C:3]([NH:5][C@H:6]([C:16]([N:18]1[CH2:47][CH2:46][CH2:45][CH2:44][C@H:19]1[C:20]([NH:22][C@H:23]([C:34]([O:36]CC1C=CC=CC=1)=[O:35])[CH2:24][CH2:25][CH2:26][NH:27][C:28](=[NH:33])[NH:29][N+]([O-])=O)=[O:21])=[O:17])[CH2:7][O:8]CC1C=CC=CC=1)=[O:4]>[C].[Pd]>[NH:1]1[CH2:50][CH2:49][CH2:48][C@H:2]1[C:3]([NH:5][C@H:6]([C:16]([N:18]1[CH2:47][CH2:46][CH2:45][CH2:44][C@H:19]1[C:20]([NH:22][C@H:23]([C:34]([OH:36])=[O:35])[CH2:24][CH2:25][CH2:26][NH:27][C:28](=[NH:29])[NH2:33])=[O:21])=[O:17])[CH2:7][OH:8])=[O:4].[CH3:23][C:34]([OH:36])=[O:35]

Participants

3

Reactant 1

HCID 178512169HCID 178512169, compound

Product 1

HCID 178476717HCID 178476717, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

150 mg of Z-Pro-Ser(Bzl)-Pip-Arg(NO2)-OBzl was reduced in the presence of palladium-carbon in the same manner as in Example 12-(4). The resulting product was purified by high-performance liquid chromatography at 12 ml/min.(flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase), subjected to Dowex 1×2 (acetate type) treatment and freeze-dried to obtain the desired compound.

Workup

  1. customThe resulting product was purified by high-performance liquid chromatography at 12 ml/min.(flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase)
  2. customfreeze-dried

Sources & evidence

ORD record
ord-6f0f2e4483dd473d99e5b31d67c1a2fc
Source dataset
uspto-grants-1992_05
Patent number
US05112947

Reaction notes

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