20-(5,5-dimethyl-1,3-dioxan-2-yl)-7alpha-(N,N-dimethylcarbamoyloxy)-1alpha,2alpha-epoxypregn-5-en-3beta-ol → 7alpha-(N,N-dimethylcarbamoyloxy)-1alpha,2alpha-epoxy-3beta-hydroxypregn-5-ene-20-carbaldehyde

Participants

Reaction Steps

The procedure of Example 36 was repeated except that 2.5 mg (0.005 mmole) of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-7α-(N,N-dimethylcarbamoyloxy)-1α,2α-epoxypregn-5-en-3β-ol was used in lieu of 2.2 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α,2α-epoxypregn-5-ene-3β,7α-diol to give 1.5 mg of 7α-(N,N-dimethylcarbamoyloxy)-1α,2α-epoxy-3β-hydroxypregn-5-ene-20-carbaldehyde (yield: 70%).

Provenance & Evidence