HuagongsheHuagongshe Chemistry Print Report · For research reference only
20-(5,5-Dimethyl-1,3-dioxan-2-yl)-7alpha-hydroxypregna-1,4-dien-3one → 21,21-Dimethoxy-20-methylpregna-1,4,6-trien-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 20-(5,5-Dimethyl-1,3-dioxan-2-yl)-7alpha-hydroxypregna-1,4-dien-3one | HCID 22843930 | — |
| Reactant | 7alpha-Hydroxy-21,21-dimethoxy-20-methylpregna-1,4-dien-3-one | HCID 54087842 | — |
| Product | 21,21-Dimethoxy-20-methylpregna-1,4,6-trien-3-one | HCID 53919224 | 84% |
Reaction Steps
The procedure of Example 5 was repeated except that 2.50 g (6.44 mmoles) of 7α-hydroxy-21,21-dimethoxy-20-methylpregna-1,4-dien-3-one was used in lieu of 3.00 g of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-7α-hydroxypregna-1,4-dien-3-one to give 2.00 g of 21,21-dimethoxy-20-methylpregna-1,4,6-trien-3-one (yield: 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112998 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-094434c527ac4a0b976e9b3ed85a6d38 |
| Source note | uspto-grants-1992_05 |