Chloroacetic Acid → 20-(1,3-Dioxolan-2yl)-3beta-acetoxy-1alpha-benzoyloxypregna-5,7-diene

Participants

Reaction Conditions

Reaction Steps

In 10 ml of diethyl carbonate was dissolved 350 mg of 20-(1,3-dioxolan-2-yl)-3β-acetoxy-1α-benzoyloxypregn-6-en-5α-ol, followed by addition of 0.1 ml of monochloroacetic acid. The mixture was stirred under heating at 100° C. in an atmosphere of argon gas for 10 hours. The reaction mixture was then worked up in the same manner as Example 124 to give 120 mg of 20-(1,3-dioxolan-2yl)-3β-acetoxy-1α-benzoyloxypregna-5,7-diene showing the following physical properties.

Provenance & Evidence