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HRID1196373

反应详情

EQUATION

反应方程式

HRID 1196373 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)OC
HCID12021

Dimethyl carbonate

C3H6O3

结构：CC(C1OCC(C)(C)CO1)[C@H]1CC[C@H]2[C@@H]3C=C[C@@]4(O)C[C@@H](OC(=O)N(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C
HCID67852911

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)O[C@@H]1C=C2C[C@@H](OC(=O)N(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](C(C)C4OCC(C)(C)CO4)CC[C@H]3[C@H]12
HCID22843925

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S(=O)(O)O
催化剂HCID1118

Sulfuric acid

H2O4S

PROCEDURE

实验过程

In 10 ml of dimethyl carbonate was dissolved 350 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α-(tert-butyldimethylsilyl)oxy-3β-(N,N-dimethylcarbamoyl)oxypregn-6-en-5α-ol, followed by addition of one drop of concentrated sulfuric acid. The mixture was stirred in an atmosphere of argon gas under ice-cooling for 1 hour. The reaction mixture was then worked up in the same manner as Example 132 to give 95 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α -(tert-butyldimethylsilyl)oxy-3β-(N,N-dimethylcarbamoyl)oxy-7α-(methoxycarbonyl)oxypregn-5-ene showing the following physical properties.

WORKUP

后处理

  1. temperaturecooling for 1 hour