Hydrochloric Acid → HCID 86745833, compound

Participants

Reaction Conditions

Reaction Steps

In 5 ml of ethanol was dissolved 105 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α-(N-phenylcarbamoyl)oxy-3β-(N-methylcarbamoyl)oxypregna-5,7-diene, followed by addition of 1 ml of 3N-hydrochloric acid, and the mixture was stirred in an atmosphere of argon gas at 40° C. for 3 hours. The reaction mixture was then worked up in the same manner as Example 156 to give 52 mg of 3β-(N-methylcarbamoyl)oxy-1α-(N-phenylcarbamoyl)oxypregna-5,7-diene-20-carbaldehyde showing the following physical properties.

Provenance & Evidence