HuagongsheHuagongshe Chemistry Print Report · For research reference only
20-(5,5-Dimethyl-1,3-dioxan-2-yl)-3beta-(methoxycarbonyl)oxypregna-5,7-dien-1alpha-ol → 3beta-Hydroxy-1alpha-(methoxycarbonyl)oxypregna-5,7-diene-20-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 20-(5,5-Dimethyl-1,3-dioxan-2-yl)-3beta-(methoxycarbonyl)oxypregna-5,7-dien-1alpha-ol | HCID 22843927 | — |
| Reactant | 20-(5,5-Dimethyl-1,3-dioxan-2-yl)-1alpha,3beta-bis(methoxycarbonyloxy)pregn-5,7-diene | HCID 67852971 | — |
| Product | 3beta-Hydroxy-1alpha-(methoxycarbonyl)oxypregna-5,7-diene-20-carbaldehyde | HCID 86745837 | 74.7% |
Reaction Steps
The reaction and workup procedures of Example 156 were repeated except that 100 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-3β-(methoxycarbonyl)oxypregna-5,7-dien-1α-ol was used in lieu of 100 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α,3β-bis(methoxycarbonyloxy)pregna-5,7-diene to give 55 mg of 3β-hydroxy-1α-(methoxycarbonyl)oxypregna-5,7-diene-20-carbaldehyde showing the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112998 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-ff3fd1e86f314e6e923c87023ab88fc8 |
| Source note | uspto-grants-1992_05 |