反应详情

Concentrated sulphuric acid (80 ml) was added at 0°-5° C. to a stirred solution of methyl cyanoacetate (28 ml) and ethyl 3-hydroxy-3-phenylbutyrate (65 g) and the mixture stirred at ambient temperature for 18 hours. The mixture was added to crushed ice (250 g) and the acidic mixture extracted with dichloromethane (3×100 ml). The combined extracts were washed with water (4×250 ml), dried over sodium sulphate and evaporated under reduced pressure to give ethyl 3-(methoxycarbonylacetamido)-3-phenylbutyrate (43.16 g), as a clear brown oil.

1. additionThe mixture was added
2. extractionthe acidic mixture extracted with dichloromethane (3×100 ml)
3. washThe combined extracts were washed with water (4×250 ml)
4. dry with materialdried over sodium sulphate
5. customevaporated under reduced pressure