Methanol → HCID 15673229, compound

Participants

Reaction Steps

A mixture of 1.98 g (4.7 mmole) of ethyl 2-[[(2R,3S) 3-(t butoxycarbonylamino)-4-cyclohexyl-2-hydroxy-1-butyl]sulfonyl]acetate and 2.3 ml of 4-(2-aminoethyl)morpholine was stirred under N2 at room temperature for 2 days. The light amber syrup was dissolved in 75 ml of ethyl acetate and washed with 3×30 ml of saturated aqueous NH4Cl followed by 30 ml of H2O. The ethyl acetate fraction was dried over Na2SO4, filtered, and concentrated. Further drying in vacuo (oil pump) gave 2.19 g (92%) of a nearly colorless, stiff foam or glass. Structure and purity were confirmed by 300 MHz NMR (CDCl3), mass spectrum, and TLC (9:1 CHCl3 --MeOH).

Provenance & Evidence